Laboratory Funding

ProjectYearProject TitleContact PI/Project
ES01376812Promoter Regulation in Response to Environmental StressPugh, Frank
Aim 1 involves collecting genome-Aim 1: Produce ChIP-exo data for 200 yeast genome-binding proteins.
Aim 2: Create web-based platforms tailored for efficient ChIP-exo analysis.

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ProjectYearProject TitleContact PI/Project
ES01376811S1Promoter Regulation in Response to Environmental StressPugh, Frank
Aim 1: Conduct ChIP-exo tests on 450 PCRP antibodies

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ProjectYearProject TitleContact PI/Project
GM05905518 Promoter Regulation in Response to Environmental StressPugh, Frank
Aim 1: Define mechanisms of co-regulation at ribosomal protein genes (RPGs).
Aim 2: Define heat shock-induced PIC co-regulation mechanisms.
Aim 3: Characterize open PICs genome-wide in animal model organisms.

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ProjectYearProject TitleContact PI/Project
HG00416012High Resolution Mapping of Function Elements in the Yeast GenomePugh, Frank
Aim 1: How Chromatin Remodelers Use Nucleosome Organizing Centers.
Aim 2: Biochemical Reconstitution of Genomic Regulatory Mechanisms.
Aim 3: Genomic Regulation of Subnucleosomal Structures.

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ProjectYearProject TitleContact PI/Project
GM1257222GENOME-WIDE STRUCTURAL ORGANIZATION OF PROTEINS WITHIN HUMAN GENE REGULATORY COMPLEXESMahony, Shaun &
Pugh, Frank
Aim 1 involves collecting genome-wide ChIP-exo data in human cell lines for a wide variety of protein-DNA complexes.
Aim 2 will develop and implement computational approaches towards pattern recognition and data distillation in ChIP-exo datasets. The results are expected to provide structural insights into macromolecular protein complex assembly on a genomic scale, and in various cell types and conditions.

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ProjectYearProject TitleContact PI/Project
GM1255921Eukaryotic Gene Regulation (EGR) Predoctoral Training ProgramPugh, Frank
The Penn State Eukaryotic Gene Regulation (EGR) Predoctoral Training Program will train a future generation of scientists in experimental, molecular and computational sciences applied towards understanding mechanisms of eukaryotic gene regulation. The training program will build upon established graduate programs in biochemistry, molecular, cellular and developmental biology, bioinformatics and genomics.

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Patent NumberPatent TitlePatent OwnerPrimary Agency
8367334Methods, systems and kits for detecting protein-nucleic acid interactionsPENNSYLVANIA STATE UNIVERSITYNIH