We are looking for talented and motivated individuals who want to be a part of the epigenomics revolution!
We developed and use the ultra-high resolution ChIP-exo mapping technique.1 Most notably, we are using yeast and human systems to define the positional and mechanistic organization of all proteins that interact with the genome. Knowledge of protein positional organization informs of biological mechanisms that we can test using various gene editing methods.2 In human systems we look at many cell types, including clinical samples that are prepared and sequenced here in Dr. Pugh’s lab. Dr. Mahony’s lab is also investigating neuronal cells.3 What is most exciting is integrating thousands of datasets into a coherent view of genome regulation. This is what is most challenging also, as it involves developing advances in computational and statistical methods. Read more Recruiting new talent to PughLab!