09 May 2014
B. Franklin Pugh, Willaman Professor in Molecular Biology and professor of biochemistry and molecular biology at Penn State University, has been honored by the University with the title of Evan Pugh Professor. The title is the highest honor that Penn State bestows on a faculty member.
Pugh has built a biochemistry research program that investigates how all genes of an organism are controlled by their environment. He uses as model systems human cells and yeast cells — both of which are among the large grouping of eukaryote cells that have a number of features in common, including a distinct nucleus. “Since the gene-transcription machinery is fundamentally the same in all eukaryotes, lessons learned from yeast provide the foundation for understanding how genes are regulated in humans, and how misregulation of genes leads to diseases such as cancer,” Pugh said. “We use yeast as a simple ‘playground’ to test ideas, then jump to human cells to see how the ideas bear out in more complex systems.”
Read more Frank Pugh Honored as an Evan Pugh Professor at Penn State